Mortality of Status Epilepticus in the First Year of Life
Abstract number :
2.196
Submission category :
Year :
2001
Submission ID :
2902
Source :
www.aesnet.org
Presentation date :
12/1/2001 12:00:00 AM
Published date :
Dec 1, 2001, 06:00 AM
Authors :
L.D. Morton, M.D., Neurology, Virginia Commonwealth University, Richmond, VA; L.K. Garnett, RN, MSHA, Neurology, Virginia Commonwealth University, Richmond, VA; A.R. Towne, M.D., Neurology, Virginia Commonwealth University, Richmond, VA; E.J. Waterhouse,
RATIONALE: Status Epilepticus (SE) is associated with a high mortality and morbidity in adults. Mortality in the pediatric population has been demonstrated to be low. Previously our group has demonstrated that the first year of life may represent a special population. The incidence of SE is highest in this group,with a higher mortality rate of 13.2% (Neurology 1998;50(Suppl 4:A444)on patients from 1989-1994. In the neonate, SE was defined using previously described definitions (Pediatrics 1993;91:128-134). This represents an updated database through December 2000.
METHODS: This study prospectively collected all SE cases from all hospitals in the Greater Metropolitan Richmond Area. SE, SE mortality and seizure types were defined as described previously (Neurology 1996;46:1029). This study includes cases from July 1989 through December 2000. This includes children ranging in age from 0 months to 16 years. Charts were reviewed for etiology, SE type, and duration.
RESULTS: A total of 598 cases of SE were identified in the pediatric population with 129 , one year of age. The overall mortality rate was 6.2% (37/598). However, the rate during the first year of life was higher at 17.8%. Further, a difference was seen between the first 6 months of life and 6 to 12 months with a mortality rate of 24% (18/75) and 9.25% (5/54). Also, the majority of all pediatric SE deaths occurred in the first year of life, 62% (23/37). SE mortality was low after the first year of life at 2.98% (14/469). Further analysis for etiology, SE type and duration is being compiled and would be availble at the time of presentation.
CONCLUSIONS: The first year of life represents a special and vunerable population with the highest mortality rates in the pediatric population. The mortality rate of 17.8 % during the first year of life in an 11 yr database confirms our reports of elevated mortality during our first 5 years ending in 1994 of 13.2%. In addition the first 6 months appears to be particularly at risk with a mortality rate of 24%. After the first year of life, mortality in the pediatric population is quite low at 2.98%.
Support: NIH P50NS25630.