Neural Signatures of Unresponsiveness vs Unconsciousness During Epileptic Seizures
Abstract number :
1.171
Submission category :
3. Neurophysiology / 3C. Other Clinical EEG
Year :
2022
Submission ID :
2204796
Source :
www.aesnet.org
Presentation date :
12/3/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:26 AM
Authors :
Urszula Gorska, PhD – University of Wisconsin Madison; Csaba Kozma, MA – University of Wisconsin Madison; Maximilian Grobbelaar, MA – University of Wisconsin Madison; Camile Mejia, BA – University of Wisconsin Madison; Cole Cimoch, MD – University of Wisconsin Madison; Jackson Haskins, BA – University of Wisconsin Madison; Elena Monai, MD – University of Wisconsin Madison; Mariel Kalkach Aparicio, MD – University of Wisconsin Madison; Cynthia Papantonatos, BA – University of Wisconsin Madison; Dillon Scott, MA – University of Wisconsin Madison; Cameron Brace, BA – University of Wisconsin Madison; Aaron Struck, PhD MD – University of Wisconsin Madison; Gulio Tononi, Prof. – University of Wisconsin Madison; Melanie Boly, PhD MD – University of Wisconsin Madison
Rationale: Loss of consciousness (LOC) is a hallmark of many epileptic seizures. While earlier studies associated it with loss of behavioral responsiveness (LOR), there is recently growing evidence that these two phenomena can be disentangled – implying that they rely on different brain networks.
Methods: In this study, we quantified LOR based on behavior (using the Consciousness Seizure Scale) and LOC using structured questionnaires sampling patient’s subjective experiences during seizures, which were completed within half an hour after seizure end. We analyzed intracranial EEG (iEEG) activity associated with 15 reports from 7 patients (2174 Electrodes) and compared slow wave activity (SWA, i.e., delta power, 1-4 Hz) in frontal and temporo-parietal regions of interest.
Results: Results suggest that increased SWA in the frontal lobe is a signature of unresponsiveness: it is increased in patients who become unresponsive during seizures, whether they are conscious or not (p< 0.01 compared to baseline and compared to responsive patients). In contrast, LOC was specifically associated with an increase in SWA in temporo-parietal electrodes (p< 0.01 compared to baseline and to conscious patients).
Neurophysiology