Neuropsychological Outcomes of Hippocampus-Sparing Anterior Temporal Lobectomy vs. Stereotactic Laser Amygdalohippocampotomy in Language-Dominant Temporal Lobe Epilepsy
Abstract number :
3.509
Submission category :
9. Surgery / 9A. Adult
Year :
2023
Submission ID :
1496
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Zeegan George, BS – University of South Florida
Elliot Neal, MD – University of South Florida; Adam Alayli, BS – Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine; Keaton piper, MD – Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine; Molly monsour, BS – USF Morsani College of Medicine; Samantha Schimmel, BS – USF Morsani College of Medicine; Long Di, MD – University of Miami Miller School of Medicine; Stephanie Maciver, MD – Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine; Joseph Boscarino, MD – Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine; Michael Schoenberg, MD – Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine; Fernando Vale, MD – Department of Neurosurgery, Medical College of Georgia at Augusta University; Yarema Bezchlibnyk, MD PhD – Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine
Rationale:
Postoperative neuropsychological deficits pose a significant challenge in the context of surgery for medically refractive temporal lobe epilepsy (TLE), particularly in the language-dominant hemisphere. Two surgical approaches have emerged to mitigate such adverse outcomes: stereotactic laser amygdalohippocampotomy (SLAH) and hippocampus-sparing anterior temporal lobectomy (HSATL). This retrospective cohort study compares the seizure control and neuropsychological outcomes of HSATL and SLAH in language-dominant TLE.
Methods:
A retrospective cohort study was conducted with 34 patients (21 female, 13 male; mean age 38.12 ± 12.37 years) undergoing surgery (22 HSATL vs. 12 SLAH) for medically intractable TLE localized in the language-dominant temporal lobe. Seizure outcomes were tracked for at least one year postoperatively, with pre- and postoperative neuropsychological testing and imaging. Statistical analysis was performed using independent T-tests, Fisher’s Exact tests, regression analysis, Mann-Whitney U tests, and Pearson correlations, with a false discovery rate (FDR)-corrected P-value of p< 0.05.
Surgery