Abstracts

RATIONALE: The objective was to determine whether ? norepinephrine (NE) release contributes to ? seizure discharge in seizure-prone sleep states, specifically slow-wave-sleep (SWS) and transitions into REM. METHODS: 5-min microdialysis samples were obtained from amygdala and locus ceruleus (LC) in 8 kittens prior to amygdala kindling and one month later (n=? 8 samples per state/per site pre & post kindling). Post-kinding data (n=2 records per subject) were divided based on ? vs. ? density of interictal discharge (IID)(n=1 record per kitten). RESULTS: Subjects had spontaneous ictal and IID discharge mostly during SWS and RTs. NE concentrations were ? in seizure-prone sleep states vs. waking states. When compared to pre-kindling NE concentrations, we found a long-term post-kindling depletion of NE in both states and at both infusion sites associated with ? spontaneous IID. See Table 1. CONCLUSIONS: Peak chronic NE depletion may reflect a rebound reduction following ? spontaneous IID.