Not all neuropsychological tests are created equal: Memory performance differences in patients with pediatric epilepsy
Abstract number :
3.458
Submission category :
11. Behavior/Neuropsychology/Language / 11B. Pediatrics
Year :
2022
Submission ID :
2233031
Source :
www.aesnet.org
Presentation date :
12/5/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:29 AM
Authors :
Kaci McLaughlin, M.Ed. – Seattle Children's Hospital; Kristina Patrick, PhD – Neuropsychologist, Neurology, University of Washington/Seattle Children's Hospital; Edward Novotny, MD – Neurologist, Neurology, University of Washington/Seattle Children's Hospital; Madison Berl, PhD – Neuropsychologist, Children's National Hospital; Brandon Almy, PhD – University of Michigan; Alyssa Ailion, PhD – Boston Children's Hospital; Donald Bearden, PhD – Children's Hospital of Atlanta; Katrina Boyer, PhD – Boston Children's Hospital; Crystal Cooper, PhD – Cook Children's Medical Center; Amanda Decrow, PhD – Atrium Health/Levine Children's Hospital; Priscilla Duong, PhD – Ann and Robert H. Lurie Children’s Hospital of Chicago; Patricia Espe-Pfeifer, PhD – University of Iowa; Marsha Gabriel, PhD – Cook Children’s Medical Center; Elise Hodges, PhD – University of Michigan; Jennifer Koop, PhD – Children's Wisconsin/Medical College of Wisconsin; David Marshall, PhD – University of Michigan; Kelly McNally, PhD – Nationwide Children's Hospital; Andrew Molnar, PhD – Vanderbilt Kennedy Center; Emily Olsen, PhD – Oregon Health & Science University; Kim Ono, PhD – Children's Healthcare of Atlanta; Brianna Paul, PhD – University of California San Francisco; Jonathan Romain, PhD – Children's Hospital of Orange County; Leigh Sepeta, PhD – Children's National Hospital; Rebecca Stilp, PhD – Norton Healthcare; Greta Wilkening, PsyD – Children's Hospital Colorado; Mike Zaccariello, PhD – Mayo Clinic; Frank Zelko, PhD – Ann and Robert H. Lurie Children’s Hospital of Chicago
This is a Late Breaking abstract
Rationale: Memory testing is an essential component of pre-surgical epilepsy evaluation, especially for temporal lobe epilepsy. There are numerous memory tests available, all with advantages and disadvantages. Data comparing superiority of certain memory tests over others are not currently available to aid clinical decision making. This study aims to evaluate whether memory performance for pediatric epilepsy patients differs depending on memory test administered and identify memory tests that most strongly predict seizure focus to the temporal lobes.
Methods: As part of the multi-site Pediatric Epilepsy Research Consortium Epilepsy Surgery Database Project, neuropsychological data were collected from pediatric patients who completed Phase I evaluation for epilepsy surgery. Patients who were administered at least one memory test were included (N = 244). Age range was 4 to 21 years (M = 12.27, SD = 4.00). The sample was 51% female and 75% white. Memory tests administered varied by site and individual patient, including the California Verbal Learning Test (CVLT), Wide Range Assessment of Memory and Learning (WRAML), Wechsler/Children’s Memory Scale (WMS/CMS), Rey Complex Figure Test (RCFT), and Child and Adolescent Memory Profile (CHAMP). Tests were sorted into subdomains of learning, immediate recall, delayed recall, and recognition for verbal and visual domains. Mixed effects linear models were run, including random effects of participant and fixed effects of evaluation number and intelligence score.
Results: Controlling for evaluation time and overall intellectual functioning, memory scores significantly differed based on tests administered for verbal learning (p < .001), verbal immediate recall (p < .001), visual learning (p=.04), and visual retention (p < .001). Differences trended toward significance for visual immediate recall (p=.06) and verbal recognition (p = .09). There were no significant differences in scores based on test given for verbal retention (p = .23) or visual recognition (p = .14). Lowest Z-scores were on RCFT (M = -1.75, SD = 1.45) and WMS/CMS Word Pairs (M = -1.46, SD = 1.20). Highest Z-scores were on verbal subtests of the WRAML (M = -0.52, SD = 1.18). There was a significant interaction effect of test type and seizure focus to the temporal lobes on memory scores (p < .001). The largest differences between patients with temporal lobe epilepsy and non-temporal lobe epilepsy were on Word Pairs (.42 SD) and verbal tests from the CHAMP (.39 SD). Results were similar when temporal lobe epilepsy patients with additional seizure foci outside the temporal lobes were excluded.
Behavior