Optical Coherence Tomography as a Strong Marker for Vigabatrin Related Visual Toxicity Based on Multifocal Electrophysiology Results
Abstract number :
2.23
Submission category :
7. Antiseizure Medications / 7D. Drug Side Effects
Year :
2021
Submission ID :
1825495
Source :
www.aesnet.org
Presentation date :
12/1/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:43 AM
Authors :
Kaleena Michael, MBChB, FRCOphth - University of Glasgow; david Keating, PhD – University of Glasgow; John Paul Leach, MD PhD – University of Glasgow; Stuart Parks, PhD – University of Glasgow; Linda Stephen, MD, PhD – University of Glasgow
Rationale: To investigate if the examination of retinal microstructures and retinal nerve fibre layer (RNFL) thickness using the Optical coherence tomography (OCT) could reveal a structural cause behind the observed timing delay in the wide-field multifocal electrophysiology (WF-mfERG) results of patients exposed to vigabatrin.
Methods: This is a prospective study of 28 participants who have all been exposed to vigabatrin. The subjects were analysed based on their WF-mfERG results where they are grouped as ‘delayed’ (based on 2ms delay in peripheral field compared to central field), or non-delayed. All patients underwent OCT macula volume and OCT RNFL. The results between the two groups are compared for statistical analysis.
Results: Analysis of the OCT microstructures based on tissue volume reveal distinctive thickness difference in the inner retinal layers of those in the ‘delayed’ group (p < 0.001). Further analysis of the retinal microstructures reveal persistent significant difference across the outer nuclear layer (ONL)(p < 0.01), ganglion cell layer (GCL) (p < 0.01) and the inner plexiform (IPL) (p < 0.01), but not the outer retinal layers.
Antiseizure Medications