Oxcarbazepine and Hyponatremia
Abstract number :
1.289
Submission category :
Year :
2001
Submission ID :
359
Source :
www.aesnet.org
Presentation date :
12/1/2001 12:00:00 AM
Published date :
Dec 1, 2001, 06:00 AM
Authors :
J.O. Rarick, BS, Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN; I.E. Leppik, MD, MINCEP Epilepsy Care, Minneapolis, MN; T.S. Walczak, MD, MINCEP Epilepsy Care, Minneapolis, MN; T.A. Tran, MD, MINCEP Epilepsy Care, Minnea
RATIONALE: Both carbamazepine (CBZ) and oxcarbazepine (OXC) are known to be associated with hyponatremia . Two patients developing clinically significant hyponatremia in switching from CBZ to OXC prompted this review of sodium (Na+) concentrations associated with these drugs.
METHODS: The MINCEP[reg] Epilepsy Care database was searched for patients using CBZ or OXC since 1/1/2000 and Na+ concentrations.
RESULTS: A total of 622 persons (312 female; 310 male) were identified as receiving CBZ, and of these, 323 persons (168 female; 155 male) had at least 1 sodium (Na+) concentration. A total of 53 persons (36 female; 17 male) were identified as receiving OXC, and 46 (30 female; 16 male) had at least one Na+ level. For CBZ, 8 females and 4 males had Na+ levels below 130 meq/L (3.7%); 14 females and 13 males had Na+ levels between 130 and 135 (8.4%), and 284 had Na+ levels above 135 (87.9%). For OXC, 5 females and 0 males had Na+ levels below 130 meq/L (11%); 8 females and 4 males had Na+ levels between 130 and 135 (26%), and 29 above 135 (63%). The proportion of OXC users with low Na+ concentrations was significantly greater by chi-square (p[lt]0.001) than for CBZ users. All five with Na+ levels below 130 had been on CBZ previously. The mean Na+ level for the five women while on CBZ was 134 (range 131-138) and 126 (range 120-129) when on OXC (p [lt]0.01). Mean age of these five women was 43.2 [plusminus]13.03 years compared with 36.7 years for our overall population.
CONCLUSIONS: These preliminary observations suggest that older women being switched from CBZ to OXC may be at risk for developing hyponatremia.
Support: MINCEP[reg] Epilepsy Care and NINDS Grant P50 NS16308