Abstracts

Because depression is a common symptom among patients with uncontrolled complex partial seizures, it is important to know how antiepileptic drugs affect this co-morbid condition. In this study, we explored the effects of oxcarbazepine, a drug effective in the treatment of complex partial seizures, upon mood in patients with mild depression associated with complex partial seizures. Twelve adults with uncontrolled complex partial seizures and mild depression who were receiving up to 2 anticonvulsant drugs, and had never been treated with oxcarbazepine, were entered into the study. The intial evaluation included a psychological evaluation which included the Montgomery-Asberg Depression Rating Scale (MADRS), the Spielberger State-Trait Anxiety Scale and the Quality of Life in Epilepsy Inventory (Qualie-89). Oxcarbazepine was initiated and titrated up to a maximum of 1200 mg per day, as tolerated ,over a 4 week period. The psychological test battery was repeated at the end of 2 months of treatment. Test scores were compared using the paired t-test. Ten patients completed the study. Two patients discontinued due to side effects (rash; dizziness and nausea). There was a significant improvement in the mean Overall Score (Baseline: 18.9 {3.99 s.d.}, Treatment: 15.6 {4.33 s.d.}, p = 0.030}, the Apparent Sadness Scale (Baseline: 1.6 {0.52 s.d.}, Treatment 0.6 {0.70 s.d.}, p = 0.004), and the Pessimism Scale (Baseline 3.0 {0.00 s.d.}, Treatment 2.6 {0.516 s.d.}, p =0.037) of the MADRS. There were no significant changes in the State-Trait Anxiety Scale or the Qualie-89. Oxcarbazepine levels ranged from 10 to 22 mcg/ml. This study provides preliminary evidence that oxcarbazepine may improve the depression associated with uncontrolled complex partial seizures. Double-blind controlled studies are warranted. (Supported by Novartis Pharmaceuticals)