Authors :
Presenting Author: Cédric Laloyaux, PhD – UCB, Brussels, Belgium
Tommi Tervonen, PhD – Kielo Research, Zug, Switzerland
Vicente Villanueva, MD, PhD – Universitario y Politecnico La Fe, Valencia, Spain; member of ERN EPICARE
Joseph Sirven, MD – Mayo Clinic, Jacksonville, FL, United States
Alison Kukla, MPH – Partners Against Mortality in Epilepsy, Chicago, IL, United States
Cecilia Jimenez-Moreno, PhD – Kielo Research, York, United Kingdom
Kerrie-Anne Ho, PhD – UCB, Slough, United Kingdom
Rationale:
Rapid and Early Seizure Termination (REST) medications prevent seizures becoming prolonged/progressing in severity, while rescue medications treat seizures that have already prolonged/progressed. Preferences of people with epilepsy/an epilepsy syndrome (PwE) and caregivers (CGs) for attributes of acute (on-demand) seizure medications were explored.
Methods:
Survey of PwE aged ≥ 18 yrs who had experienced ≥ 1 prolonged seizure (PS) of ≥ 2 min in past 12 mos and CGs (aged ≥ 18 yrs) of PwE aged ≥ 12 yrs from France/Italy/Poland/Spain/UK/US. A discrete choice experiment (DCE) was used to elicit treatment preferences (analyzed using multinomial logit models) and a willingness to wait exercise for administration of acute seizure medication.Results:
135 adult PwE, 120 CGs of adults, 119 CGs of adolescents took part (N=374): median age was 45 yrs, 242 (65%) were female. Of 239 CGs, 133 (56%) were parents. Overall, 173 (46%) participants reported generalized or bilateral/tonic-clonic as the most common seizure type; 193 (52%) reported an average of 3–5 seizures/mo and 214 (57%) reported an average duration of 1–4 min for the most common seizure type over past 12 mos. 212 (57%) participants reported using oral acute medication for PS. In DCE, all attributes significantly influenced participants’ treatment preferences (p< 0.05);