Abstracts

Vagus Nerve Stimulation (VNS) has been assoicated with stimulus-induced temporary voice changes post-operatively. We reviewed patient reports of voice changes to determine their frequency and impact on quality of life. All clinic records of VNS implants at the Regional Epilepsy Center between November, 2001 - present were retrospectively analyzed. Demographic information collected included age, gender, stimulation settings, and seizure frequency. Results were recorded. We evaluated if seizures were controlled, if patients felt a voice change occurred, and if this has affected quality of life. Our on-going review produced 29 evaluations of the 101 patients with VNS implantations. Ages ranged from 10-86 years old. Of the 29 evaluations, there were 12 females and 17 males. Of the 29 patients evaluated, 12 reported no voice change and 17 reported a voice change. Of these 17 reported changes, 6 were significant and 11 were not. 4 patients with the significant voice change felt their quality of life was affected to the degree that 3 of the 4 had the VNS turned off. 27 of the 29 patients reported a reduction or freedom of seizures. We found VNS frequently affects voice quality but without affecting quality of life. While quality of life was affected for 4 of 29 patients, seizure reductions may provide significant benefits. Patients reported most voice changes early and reduced later on. (Supported by Aurora Health Care.)