Platelet Values May Be Associated with Outcome in Children with Febrile-infection Related Epilepsy Syndrome (FIRES)
Abstract number :
1.07
Submission category :
2. Translational Research / 2A. Human Studies
Year :
2023
Submission ID :
92
Source :
www.aesnet.org
Presentation date :
12/2/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: YI-Chen Lai, MD – Baylor College of Medicine
Eyal Muscal, MD – Baylor College of Medicine; James Riviello, MD – Baylor College of Medicine
Rationale: An active systemic inflammation has been described in individuals with new onset refractory status epilepticus (NORSE) and febrile-infection related epilepsy syndrome (FIRES). Serum cytokine profiles may be associated with treatment response or outcome implicating systemic inflammation in the pathology of NORSE and FIRES. In sepsis, decreasing platelets (plt) has been hypothesized to reflect endothelial damage resulting from systemic inflammatory response. Thrombocytopenia (< 150K) beyond the first three days of sepsis is associated with bad outcome. Therefore, we hypothesize that plt as a potential marker of systemic inflammation may differ between good and bad outcomes in children with FIRES and that thrombocytopenia may be associated with bad outcome.
Translational Research