Post Implantation Effects of Responsive Neurostimulation Devices (RNS) : A Case Series
Abstract number :
3.319
Submission category :
9. Surgery / 9C. All Ages
Year :
2023
Submission ID :
747
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Joel Oster, MD – Tufts Medical Center
James Kryzanski, MD – Neurosurgery – Tufts Medical Center
Rationale: RNS devices ameliorate seizures incrementally over time but there may be post implantation seizure reduction that may occur without device or other significant or readily identifiable clinical changes which may represent a so called post implantation effect. Currently the literature currently contains only limited anecdotal reports of this observation.
Methods: In a retrospective chart review and or analysis of patients implanted with RNS devices, twenty two such cases in total occurred at our institution and time to seizure activity was inventoried and analyzed
Results: There were three cases which had seizure reduction not accounted for by other apparent clinical variables beyond what the predicted seizure frequency would be based on the habitual seizure frequency without device and or medication changes or other readily identifiable variables.
Conclusions: There is a quantifiable amount or percentage of patients who exhibit what we term a post implant effect where limited seizure activity may occur after RNS insertion. The underlying mechanisms for such phenomenology remain unknown and may be the subject of further detailed analysis and study.
Funding: None
Surgery