Authors :
Presenting Author: Daniel Weisholtz, MD – Brigham and Women's Hospital
Alexa Roy, BA – Brigham and Women's Hospital; Ava Sanayei, BA – Brigham and Women's Hospital; Brannon Cha, BA – Brigham and Women's Hospital; Dustine Reich, BA – Brigham and Women's Hospital; David Silbersweig, MD – Brigham and Women's Hospital; Barbara Dworetzky, MD – Brigham and Women's Hospital
Rationale:
Postictal psychiatric symptoms (PPS) are a relatively common but understudied phenomenon in epilepsy. The mechanisms by which seizures contribute to worsening in psychiatric symptoms are unclear. We aimed to identify PPS prospectively during and after admission to the epilepsy monitoring unit (EMU) in order to characterize the postictal physiologic changes leading to PPS.
Methods:
We prospectively enrolled patients admitted to the EMU and administered repeat psychometric questionnaires during and after their hospital stay in order to assess for postictal exacerbations in four symptom complexes: anger/hostility, anxiety, depression, and paranoia. Electroclinical and electrographic seizures were identified from the EEG recordings, and seizure durations were measured. The severity of postictal slowing was calculated as the proportion of postictal theta/delta activity in the postictal EEG relative to the preictal EEG using the Hilbert transform.
Results:
Among 34 participants, eight demonstrated significant increases in at least one of the four symptoms (the PPS+ group) within three days following the first seizure. The most common PPS was anger/hostility, experienced by 7/8 participants with PPS. Amonth the 8 PPS+ participants, four experienced more than one PPS. As compared to those without PPS (the PPS- group), the PPS+ group demonstrated a greater degree of postictal EEG slowing at 10 minutes (p =0.011) and 20 minutes (p=0.025) following seizure termination. They also experienced significantly more seizures during the study period (p=0.005). There was no difference in seizure duration between groups.
Conclusions:
Postictal psychiatric symptoms including anger/hostility, anxiety, depression, and paranoia may be more common than recognized. In particular, postictal increases in anger and irritability may be particularly common. We provide physiological evidence of a biological mechanism as well as a demonstration of the use of quantitative electroencephalography toward a better understand postictal neurophysiology.
Funding: This study was funded by a grant from the Endowed A.J. Trustey Epilepsy Research Fund