Prevalence of dementia and seizure-free outcome for 12 months in patients with late-onset epilepsy with unknown etiology
Abstract number :
406
Submission category :
16. Epidemiology
Year :
2020
Submission ID :
2422750
Source :
www.aesnet.org
Presentation date :
12/6/2020 12:00:00 PM
Published date :
Nov 21, 2020, 02:24 AM
Authors :
Naoto Nagino, TMG Asaka Medical Center; Yuichi Kubota - TMG Asaka Medical Center; Hidetoshi Nakamoto - TMG Asaka Medical Center; Satoru Miyao - TMG Asaka Medical Center; Tomohiro Kodama - TMG Asaka Medical Center; Hirokazu Oguni - TMG Asaka Medical Center
Rationale:
Incidence and prevalence of epilepsy increase with age, especially over the age of 65 years. Several identified etiologies cause late-onset epilepsy. However, approximately 50% of the etiologies of late-onset epilepsy were unexplained. A possible association between late-onset epilepsy with unknown etiology (LOEU) and dementia has been suggested. To date, no conclusions were identified in LOEU. The aim of this study is to evaluate the prevalence of dementia in our patients with LOEU and seizure-free outcome for 12 months in the LOEU population followed.
Method:
A total of 89 patients diagnosed LOEU after the age of 65 years were retrospectively identified at our epilepsy center. We examined baseline characteristics of the patients, electroencephalogram findings, imaging findings, the prevalence of dementia, and seizure-free outcome for 12months.
Results:
The most frequent seizure types were focal impaired awareness seizure (77.5%), followed by focal to bilateral tonic-clonic seizures (38.2%) and focal awareness seizure (22.9%). Prevalence of dementia was 34.8% among our patients. Nearly two-thirds of LOEU patients followed achieved seizure-free for 12months. Despite the dementia staging varies among our patients, there was no significant correlation between the dementia and seizure-free outcome for 12months among these LOEU patients.
Conclusion:
The prevalence of dementia in our patients with LOEU was 34.8%. This number was substantially higher than that of older patients with epilepsy in general population. A relatively low dose of single antiepileptic drug was effective to seizure control in our patients at follow-up. Dementia seemed not to affect the outcome of seizure-free for 12 months.
Funding:
:This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Epidemiology