Abstracts

Rationale: To assess the efficacy of intracranial surgery for children who had intractable epilepsy due to Tuberous sclerosis complex(TSC). Additionally we compared seizure-free group with non seizure free group to identify the factors that lead to good surgical result. Methods: Between Jan. 2001 to Dec. 2005, 11 patients with TSC underwent intracranial surgery for intractable epilepsy. There were 7 males and 4 females aged 1 to 16 years at the time of surgery(mean: 6.7years). Reduction rate of seizure frequency was analyzed at 1-year follow-up(1 FU) visit after surgery. And based on the medical records, all the possible factors that contributed to surgical result were analyzed retrospectively. Results: No patient had previous history of intracranial surgery. Intracranial surgery included 4 tuber resections, 5 lobectomies, 1 tuber resections and lobectomies, and 1 corpus callosotomy. 6 patients were seizure free at 1FU. In seizure free group, mean age of seizure onset was 12.17 10.34 months, however non-seizure free group was 5.80 0.84 months (p-value 0.193). Mean duration from onset of seizure to resective surgery in seizure-free group was 98.17 53.87 months, compare to 96.20 41.58 months in non-seizure free group(p-value 0.948). Developemental scale of preoperative evalaution, percentile to normal population in seizure free group was 66.50 30.74 percentile, compare to non-seizure free group 68.33 29.38. (p-value 0.930) Every patient who had history of infantile spasm eventually developed recurrence. Conclusions: Unlike previous reports, late onset of initial seizure, better developmental scale and shorter duration to surgery did not correlate statistically with surgical outcome. However age of seizure onset still presents those were the most import factors for better prognosis. Large samples and long term follow-up study should be done to clarify the exact factors.