Abstracts

Rationale: Prolonged febrile seizures (FS) and status epilepticus (SE) are one of the most urgent neurological conditions in childhood and associated with neurological sequelae and increased risk of epilepsy. SE accounts for 5 % of children with FS. Because the prevalence of FS in Japan (8-10%) is 2-3 times higher than those reported in other countries (2-4%), the incidence of prolonged FS or SE would be also high. The aim of the study is to investigate an incidence of prolonged FS, because of paucity of the epidemiological data in Japan. Methods: A cross sectional questionnaire-based survey for a history of FS at the health-check program for three-year-old children in Izumo, Japan, from Apr, 2016 to March, 2017. A questionnaire about FS was sent to all participating families prior to the program. Prolonged FS and SE were defined as lasting at least 10 and 30 minutes, respectively. Results: The recovered questionnaires were 1,085 of 1,551 (70%). 136 children had a history of FS (12.3%). Children with prolonged FS and particular FS which did not cease at the arrival to a hospital were 21 (21/136, 15%) and 13 (13/136, 11%), respectively. The number of children with status epilepticus were 7 (7/123, 5.7%). The incidence of prolonged FS and SE was 645 and 215 per 100,000, respectively, in the first 3 years of life. Conclusions: Our results showed a high incidence of prolonged FS including SE. Because of the high prevalence of FS among children in Japan, shown as in our results, the frequency of prolonged FS was also high. These suggest prehospital treatment is necessary for the early seizure termination. Funding: No fundings