Propagation of Physiological High-frequency Oscillations
Abstract number :
1.022
Submission category :
1. Basic Mechanisms / 1C. Electrophysiology/High frequency oscillations
Year :
2022
Submission ID :
2203923
Source :
www.aesnet.org
Presentation date :
12/3/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:22 AM
Authors :
Yoshio Shiimoto, Medical Student – Yokohama City University; Riyo Ueda, MD, PhD – Wayne State University; Yongje Jeon, Medical Student – Yokohama City University; Kazuki Sakakura, MD – Wayne State University; Yu Kitazawa, MD, PhD – Wayne State University; Masaki Sonoda, MD, PhD – Assistant Professor, Yokohama City University; Eishi Asano, MD, MS, PhD – Professor, Wayne State University
Rationale: Epilepsy presurgical evaluation includes functional brain mapping to localize the eloquent areas. To this end, the measurement of task-related high-frequency oscillations (HFOs) is routinely employed in many tertiary epilepsy centers. The present study aimed to visualize and assess the propagation dynamics of task-related HFOs during a visuomotor task on an iPad.
Methods: We studied eight children with drug-resistant focal epilepsy who completed a one-back task implemented in the Lumosity cognitive game during extraoperative subdural EEG recording. Each participant was instructed to indicate, with a finger tapping, if a given visual stimulus was repeated or new. Time-frequency analysis quantified the percent change of HFO amplitude (70-110 Hz) at given electrode sites and 10-ms time bins. We built the whole-brain level video atlas animating the dynamics of task-related HFO modulations.
Results: Both repeated and new visual stimuli elicited HFO augmentation initially in the calcarine and subsequently in the fusiform region. Repeated stimulus-related HFO augmentation was confined to the posterior fusiform region at 100-230 ms post-stimulus onset. New stimulus-related HFO augmentation was likewise noted in the posterior fusiform region at the same time window but subsequently propagated anteriorly at 230-340 ms post-stimulus onset (Figure 1). Finger tapping-related HFO augmentation initially involved the contralateral precentral gyrus and propagated to the postcentral gyrus with an inter-gyral onset-to-onset delay of 100 ms (Figure 2).
Conclusions: The study provided preliminary evidence that the anterior fusiform region may support the recognition of new visual stimuli. Precentral-to-postcentral HFO propagation may reflect neural activations supporting motor execution followed by somatosensory, proprioceptive feedback. Video atlas may be a valuable tool to readily digest the propagation dynamics of neural activations supporting sensory and motor functions.
Funding: NIH grant NS64033 (to E. Asano)
Basic Mechanisms