Quality of Life and Depression Phenotypes in Young Adults with Epilepsy
Abstract number :
3.274
Submission category :
6. Cormorbidity (Somatic and Psychiatric)
Year :
2022
Submission ID :
2205049
Source :
www.aesnet.org
Presentation date :
12/5/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:27 AM
Authors :
Erica Johnson, PhD – University of Washington; Janelle Wagner, Clinical Psychologist – Research Associate Professor, Comprehensive Epilepsy Center, Medical University of South Carolina; Kaylee Sarna, Research Assistant – Case Western Reserve University; Farren Briggs, Assistant Professor – Case Western Reserve University; Martha Sajatovic, Professor – Case Western Reserve University; Robert Fraser, Professor – University of Washington; cam Escoffery, Professor – Emory University; Ross Shegog, Professor – University of Texas-Houston; Elaine Kiriakopoulos, Assistant Professor – Dartmouth Geisel School of Medicine; Barbara Jobst, Professor – Dartmouth Geisel School of Medicine; Tanya Spruill, Associate Professor – NYU; Mary Janevic, Associate Research Scientist – University of Michigan
Rationale: There are limited data on psychosocial functioning in young adults with epilepsy (YAWE) despite myriad milestones achieved during this phase (e.g., post-high school education, vocational achievement, romantic relationships, independent living). YAWE are often incorporated into larger adult studies without emphasis on specific development associated with 18 to 24 and 25 to 29 age spans. In an epidemiological study using administrative data (Wagner et al., 2016), 51% of YAWE had a behavioral health/psychological comorbidity; this has implications for quality of life. The purpose of this study was to use aggregate data from the Managing Epilepsy Well Integrated Database (MEW-DB) from 15 self-management studies to: (1) describe sociodemographic characteristics and (2) analyze sociodemographic, seizure severity, self-management, and mood variables as predictors of QoL of YAWE aged 18 to 29.
Methods: The MEW-DB was queried for all subjects aged 18 to 29 with completed standardized psychosocial measures of QoL (QoLIE-10), mood (PHQ-9), epilepsy-self-management (Epilepsy Self-Management Scale; ESMS), and demographics. Of 418 subjects in this group, n=237 had sufficient data. The PHQ-9 was divided into cognitive (COG) and somatic (SOM) symptoms according to 2 phenotypes of depression in epilepsy (Rayner et al., 2016). Zero-order correlation coefficients were calculated on all variables of interest. Subsequent analyses were conducted: (1) bivariate correlation analysis of COG and QoL, (2) bivariate correlation analysis of SOM and QoL, and (3) stepwise regression analyses of predictors of QoL (in this order: demographic variables; seizure severity; ESMS total score; and, in four separate analyses, PHQ-9 total score; PHQ-9 suicidality item; PHQ-9 COG; and PHQ-9 SOM).
Results: The null hypothesis holds no relationships. The alternative hypothesis, based on published work, is COG and SOM symptoms of depression correlate with QoL, and each exerts independent effects. We would expect total depression, suicidality, COG symptoms, and SOM symptoms exert independent effects on QoL beyond what is explained by seizure severity and demographic variables alone. Depression had a strong relationship with QoL (r=0.703); all other relationships were weak (r > -0.21 and < 0.21). Full results are pending.
Cormorbidity (Somatic and Psychiatric)