Quantitative MR Analysis of Frontal Lobe and Corpus Callosum in Frontal Lobe Epilepsy.
Abstract number :
1.201
Submission category :
Year :
2001
Submission ID :
2712
Source :
www.aesnet.org
Presentation date :
12/1/2001 12:00:00 AM
Published date :
Dec 1, 2001, 06:00 AM
Authors :
H.W. Lee, M.D., Epilepsy and Sleep Disorder Program, Neurology, Samsung Medical Center, Seoul, Republic of Korea; S.B. Hong, M.D., Epilepsy and Sleep Disorder Program, Neurology, Samsung Medical Center, Seoul, Republic of Korea; E.K. Lee, Neuroimaging Lab
RATIONALE: Quantitative MRI studies have been carried out in the several psychiatric diseases and the mesial TLE patients, but not in the nonlesional neocortical epilepsies. This study was performed to provide a pilot data on MRI quantification of the frontal lobe (FL) and the corpus callosum (CC), and to document possible relationship with neuropsychological (NP) performance in the normal controls and the FLE patients.
METHODS: The FL volume and the mid-sagittal CC area were measured in 34 normal and 18 cryptogenic FLE subjects. The CC area was measured in its entirety and in seven subregions (A1 to A7). A mid-sagittal intracranial surface (MIS) and whole brain volume (WBV) were also measured to calculate the (FL or CC)/MIS and (FL or CC)/WBV ratios. NP tests were performed in 32 normal and 13 FLE subjects.
RESULTS: The absolute FL volume was not significantly different between normal and FLE groups (mean 375.2 [plusminus]23.9 vs. 361.9 [plusminus]49.9 cm3, p [lt] 0.05), but significantly reduced in left FLE than in right FLE (mean 342.3 [plusminus]20.4 vs. 377.2 [plusminus]63.0 cm3, p [lt] 0.05). The MIS was not different between normal and FLE subjects, whereas the WBV of FLE was significantly smaller than that of normal controls (p [lt] 0.05). The CC/MIS ratios of total CC and its subregions were significantly smaller in FLE patients (p [lt] 0.05) except for A1 and A6. The CC/MIS ratio of A2 (genu) showed the greatest reduction. The areas of A2 to A5 were positively correlated with the absolute FL volume. Decreased FSIQ, PIQ (full-scale and performance IQ) scores showed significant correlation with the reduced FL volume. Abnormal results of WCST (Wisconsin card sorting test) were associated with decreased FL and CC.
CONCLUSIONS: This study showed decreased FL volume in left FLE and reduced CC area in left and right FLE associated with some specific frontal lobe dysfunction. These changes might be produced from recurrent seizure discharges and their propagation from one FL to the opposite hemisphere through the CC.