Recent Neurodevelopmental Outcomes of Extremely and Very Preterm Birth
Abstract number :
3.352
Submission category :
11. Behavior/Neuropsychology/Language / 11B. Pediatrics
Year :
2023
Submission ID :
1077
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: JUNGHYE BYEON, MD PhD – Korea University
Baik-Lin Eun, . – Korea University; young kyu Shim, . – Korea University
Rationale: Technology and advances in medical knowledge increased the survival of children born preterm. Preterm children have a high risk for neurodevelopmental delay. This study aims to evaluate recent neurologic outcomes in around 1.5 years with prematurity.
Methods: This study was a prospective longitudinal cohort study from 2018 to 2022 at a single tertiary hospital. Preterm children with gestational age less than 32 weeks or birth weight less than 1500g are followed up and evaluated Magnetic Resonance Imaging and neurodevelopment and behavior with Sequenced language Scale for Infants (SELSI), Bayley Scales of Infants and Toddler Development third edition, Childhood Autism Rating Scale second edition (CARS2) and Social Maturity Scale (SMS) in their corrected 18 months age.
Results: In total, 54 children were assessed: 9 extremely preterm and 45 very preterm children. Earlier preterm needed positive pressure ventilation (P< 0.001), and showed more than three intraventricular hemorrhage grade (P=0.03), but not correlated with periventricular leukomalacia (PVL) in MRI. Motor, language, and cognitive delay under two standard deviation were 9.3%, 3.7%, 3.7% retrospectively. Mild delay under one standard deviation were 13%, 18.5%, 5.6% retrospectively. All neurodevelopmental scores were correlated with others intersection. Motor is correlated with language, cognition, adaption, and PVL (P< 0.05). Language is correlated with all other sections (P< 0.05) than CARS2. Cognition is positively correlated with all other section including CARS2, negatively correlated with mother’s age (P=0.013). Neonatal seizure with antiepileptics less than one month did not induce significant neurodevelopmental delay.
Behavior