REGIONAL VOLUME CHANGES OF BRAIN IN JUVENILE MYOCLONIC EPILPESY
Abstract number :
3.156
Submission category :
Year :
2002
Submission ID :
1572
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Seung Bong Hong, Woo Suk Tae, Won Chul Shin. Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
RATIONALE: MRI scans of patients with idiopathic generalized epilepsy are normal on visual assessment. Only one study showed an increase in cortical gray matter in the mesial frontal lobes of patients with juvenile myoclonic epilepsy (JME). We investigated regional volume changes of brain in JME patients.
At the end of this presentation, participants should be able to discuss structural abnormalities of JME.
METHODS: Nineteen JME patients (22.6[plusminus]5.2 year-old, 6 males, 13 females) and 19 normal controls (23.0[plusminus]7.3 year-old, 6 males, 13 females) underwent 1.6 mm thickness whole brain SPGR MRI. Exact mid-sagittal image was obtained with image reconstruction and geometric correction. According to the Witelson[ssquote]s work, the mid-sagittal area of corpus callosum was divided into seven subregions (a1 to a7 from anterior to posterior) and their areas were measured. Volumes of hippocampus, frontal lobe and whole cerebrum were measured with a semi-automated method. The difference of each measurement between JME and normal groups were tested by t-test and ANCOVA (adjusted by age and cerebral volume).
RESULTS: There was no significant difference of cerebral volume between groups (JME: 1,113[plusminus]123 cm3, Normal: 1,093[plusminus]60 cm3, p=0.52, t-test). Left hippocampus was smaller in JME (JME: 2.62[plusminus]0.26 cm3, Normal: 2.78[plusminus]0.24 cm3, p=0.032, ANCOVA) whereas left frontal lobe was significantly larger in JME (JME: 213.9[plusminus]30.4 cm3, Normal: 191.3[plusminus]15.1 cm3, p=0.004, ANCOVA). The areas of rostrum (p[lt]0.0001, ANCOVA) and rostral body (p=0.044, ANCOVA) in corpus callosum were significantly smaller in JME.
CONCLUSIONS: Rostrum and rostral body of corpus callosum, and left hippocampus were smaller in JME while left frontal lobe was larger in JME. These findings suggest a structural abnormality of left frontal lobe in JME, which may be related to microdysgenesis. Volume reduction of portions in corpus callosum could be related with axonal agenesis caused by microdysgenesis or recurrent seizures.
[Supported by: the Korean Ministry of Science and Technology under the National Research Laboratory(NRL) program (2000-N-NL-01-C-157)]