SIGNIFICANCE OF WECHSLER INTELLIGENCE SCALE FOR CHILDREN (WISC) FOR LATERALIZING EPILEPTIC FOCUS IN CHILDHOOD EPILEPSY
Abstract number :
2.162
Submission category :
Year :
2002
Submission ID :
760
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Kyunghwa Lim, Hoon Chul Kang, Heung Dong Kim. Dept. of Pediatrics, Epilepsy Center, Inje University College of Medicine, Sang-gye Paik Hospital, Sang-gye 7 Dong, Nowon Gu, Seoul, Korea
RATIONALE: Lateralization of epileptic focus is important to evaluate epileptic patients for determination of epileptic lesion especially in presurgical evaluation. Many adult epilepsy was studied for the significance of intelligence test for localizing epileptic focus by using the discrepancies of sub-scale examinations, but data for pediatric epileptic patients is not well published yet. We studied to disclose the lateralizing value of intelligence test in childhood epilepsy patients.
METHODS: Korean Version of Wechsler Intelligence Scale for Children (KEDI-WISC) was applied for intelligence testing in 100 childhood epilepsy patients (mean age: 9.91 yrs., age range: 5-18 yrs., M:F ratio: 1/1.04) diagnosed at the department of pediatrics and epilepsy center at Sang-gye Paik Hospital. The clinical characteristics of patients including age, sex, handedness, epileptic syndrome, EEG findings, MRI results were reviewed in relation to verbal and performance IQ. The discrepancy between verbal and performance IQ scores were compared with the lateralization of epileptic lesion from EEG and MRI findings to reveal the significance of lateralizing value of intelligence test.
RESULTS: 1) Full scale IQ scores were ranged from 43 to 133 (mean: 88.4[plusminus]22.8), verbal IQ[ssquote]s were from 44 to 129 (mean: 91.0[plusminus]20.2), and performance IQ[ssquote]s were from 38 to 138 (mean: 87.5[plusminus]24.2) in epileptic children.
2) Full scale, verbal, and performance IQ[ssquote]s were significantly lower in patients with various abnormal brain MRI findings (p[lt]0.05).
3) Significant discrepancy between verbal and performance IQ scores were noticed in 49 patients. Lower verbal IQ[ssquote]s were observed in 17 patients, and lower performance IQ[ssquote]s were in 32 cases.
4) Patients with significant low performance IQ scores were associated with abnormal MRI and/or EEG findings in non-dominant hemisphere, and those with significant low verbal IQ scores showed abnormal MRI and/or EEG features in dominant hemisphere (p[lt]0.05).
5) Patients with right hemispheric brain lesions had significantly lower performance IQ than other patients (p[lt]0.05).
6) EEG findings were more closely related to the lateralizing value of IQ score discrepancies than MRI.
CONCLUSIONS: WISC has still importnat role to provide lateralizing value of hemispheric pathology in childhood epilepsy with MRI and EEG findings.