Abstracts

Sleep-wake State Modulation Alteration of Interictal Epileptiform Spikes in Temporal Lobe Epilepsy

Abstract number : 3.126
Submission category : 3. Neurophysiology / 3C. Other Clinical EEG
Year : 2023
Submission ID : 1088
Source : www.aesnet.org
Presentation date : 12/4/2023 12:00:00 AM
Published date :

Authors :
Presenting Author: Aisha Abdulrazaq, MD – Mayo Clinic

Filip Mivalt, MS – Bioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA; Vaclav Kremen, MS, PhD – Bioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA; sladky vladimir, MS – 1. Bioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA; Andrea Duque-Lopez, Research Fellow – Bioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA; Nicholas Gregg, MD – Bioelectronics Neurophysiology and Engineering Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN, USA; Brian Lundstrom, MD, PhD – Mayo Clinic; Erik St. Louis, MD – Mayo Clinic; Benjamin Brinkmann, PhD – Mayo Clinic; Timothy Denison, Professor – 9. Department of Engineering Science, University of Oxford; MRC Brain Network Dynamics Unit, University of Oxford, OX3 7DQ UK; Kai Miller, MD, PhD – Neurosurgery, Mayo Clinic; Jamie Van Gompel, MD – Neurosurgery, Mayo Clinic; Gregory Worrell, MD., PhD – Mayo Clinic

Rationale: Sleep-wake states are known to modulate interictal epileptiform spikes (IES) rates and seizure occurrence, but most data is qualitatively collected over relatively brief periods of time. Prior studies report  IES rate in mesial temporal lobe epilepsy (mTLE) is highest during non-rapid eye movement (NREM) sleep, intermediate in wakefulness, and lowest during REM sleep. Here, we examine the effect of sleep-wake brain states on IES rate using long-term continuous recordings from human hippocampus

Methods: IES and seizures were recorded over 90 days in five people with bilateral mTLE using the investigational Medtronic Summit RC+STM, an investigational intracranial neural sensing and stimulation device. Four leads (4-contacts each lead) targeted the bilateral thalami and hippocampi. The device enables continuous streaming of local field potentials that are processed using automated algorithms for sleep-wake classification, IES detection and seizure detection. The sleep-wake classifier has an overall accuracy of 0.908 ± 0.023 scored using simultaneous LFP and polysomnography recordings.

Results: The results revealed significant circadian patterns with the frequency of IES in NREM greater than in REM and wakefulness (p< 0.001
Neurophysiology