Sodium Valproate Use Associated with Thinning of the Motor Cortex in Juvenile Myoclonic Epilepsy – a Seizure Protective Role?
Abstract number :
3.229
Submission category :
5. Neuro Imaging / 5A. Structural Imaging
Year :
2023
Submission ID :
960
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Bernardo Crespo Pimentel, MD – Paracelsus Medical University
Giorgi Kuchukhidze, MD, PhD – Paracelsus Medical University; Fenglai Xiao, MD, PhD – Department of Clinical & Experimental Epilepsy – UCL Queen Square Institute of Neurology; Lorenzo Caciagli, MD, PhD – Department of Clinical & Experimental Epilepsy – UCL Queen Square Institute of Neurology; Julia Hoefler, MD – Paracelsus Medical University; Martin Kronbichler, BSc – Paracelsus Medical University; Lucas Rainer, MSc, PhD – Paracelsus Medical University; Christian Vollmar, MD, PhD – Ludwig-Maximilians-University of Munich; John Duncan, MD, PhD – Department of Clinical & Experimental Epilepsy – UCL Queen Square Institute of Neurology; Eugen Trinka, MD, MSc – Chair, Department of Neurology, Paracelsus Medical University; Britta Wandschneider, MD, PhD – Department of Clinical & Experimental Epilepsy – UCL Queen Square Institute of Neurology; Matthias Koepp, MD, PhD – Department of Clinical & Experimental Epilepsy – UCL Queen Square Institute of Neurology
Rationale:
Sodium valproate (VPA) remains the most effective anti-seizure medication (ASM) in idiopathic generalized epilepsies (IGEs) and causes fewer cognitive side effects in IGE than in focal epilepsies. This is supported by neuroimaging studies showing a normalizing effect of VPA for co-activation of the left motor cortex during working memory tasks. VPA use in mixed cohorts of focal and generalized epilepsies was associated with parietal lobe thinning and reduced brain volume. 3 With this study, we aimed to investigate VPA related syndrome-specific chances on cortical morphology in JME and focal epilepsies.
Methods:
In this cross-sectional retrospective analysis, we matched a group of JME patients (n=79, 36 on VPA) with focal epilepsy cases (n=55, 27 on VPA) and a control group (n=71) who obtained 3T MRI at two European epilepsy centers. Vertex-wise cortical thickness and volume were estimated through a surface-based analysis and datasets were harmonized for scanner-related effects. We performed a vertex-wise analysis with age, sex and presence of drug resistant disease as covariates controlling family wise error (FWE) at p< 0.01.
Neuro Imaging