Abstracts

Rationale: Status epilepticus (SE) is an important cause of mortality worldwide. Information regarding clinical features and outcome in Uganda is limited. The main objective was to describe the clinical presentations and outcome of patients admitted in Mulago hospital with status epilepticus.

Methods: In a retrospective study, twenty one patients with confirmed status epilepticus (SE) were enrolled between January 1,2022 and December 31,2022 . Socio-demographics, clinical features, anti-seizure medication and outcomes were collected. Patients with SE were followed documenting outcomes on discharge as survival versus death.
Results: Of the twenty one patients in this cohort, 69% were male, majority aged less than 60 years. Thirty eight percent were known patients with epilepsy, while 62% with status epilepticus were presenting for the first time with seizures. Nineteen percent of the patients died within the study period with half of the deaths occurring before hospital discharge. Males had significantly higher seizure durations than females; p=0.023 95%CI 1.86 (1.12, 3.07). In addition, patients that died recorded significantly longer SE episodes (55 minutes) than those that lived (19.59min); p=0.018. Patients with known epilepsy who presented in status were more likely to have better outcomes and less than 20min seizure frequency

Conclusions: Patient Identification of clinical profile of patients with status epilepticus is important in design of future studies to assess the seizure frequency and to identify various prognostic factors. Nevertheless, studies with larger samples may be necessary to clarify these results

Funding: This study was supported by the National Institute of Health, National Institute of Neurological Disorders and Stroke (NINDS). Research training and mentorship tp strengthen brain health across the lifespan in Uganda. D43NS118560.