Stereotactic-EEG-guided Multiple Electrode Stereo-conformal Radiofrequency Thermocoagulation for the Treatment of Drug-resistant Insular Epilepsy
Abstract number :
1.223
Submission category :
4. Clinical Epilepsy / 4C. Clinical Treatments
Year :
2023
Submission ID :
184
Source :
www.aesnet.org
Presentation date :
12/2/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: haoran ding, MD – Sanbo brain hospital capital medical university
yuguang guan, - – sanbo brain hospital capitalmedicaluniversity; xiongfei wang, - – sanbo brain hospital capitalmedicaluniversity; jing wang, - – sanbo brain hospital capitalmedicaluniversity; jian zhou, - – sanbo brain hospital capitalmedicaluniversity; guoming luan, - – sanbo brain hospital capitalmedicaluniversity
Rationale:
This study aims to retrospectively analyze the safety and efficiency of stereo-electroencephalography (SEEG)-guided multiple electrodes stereo-conformal radiofrequency thermocoagulation (RFTC) in the treatment of drug-resistant insular epilepsy.
Methods:
Twenty three patients with drug-resistant insular epilepsy underwent SEEG-guided multiple electrode stereo-conformal RFTC at Functional Neurosurgery Department of Beijing Sanbo brain hospital. Patients were retrospective analyzed from February 2016 to January 2020. Standard presurgical evaluation, including semiology, video electro-encephalographic recordings, magnetic resonance imaging, positron emission tomography, and magneto-encephalography were performed on all the 23 patients suggesting that the epileptogenic focus located in the insula lobe. According to the diagnosis, electrodes implantation were designed. As the epileptogenic focus inside the insular lobe was verified, the multi-electrode stereo-conformed RFTC treatment was performed. Patients were followed up in hospital, outpatient department, or by telephone. Engel classification was used to evaluate the prognosis and the operative complications were observed.
Results:
All the 23 patients were followed up at 3, 6, 12 and 24 months after surgery. By the last follow-up, 12 patients were seizure free (Engel I), Five patients had rare seizures (Engel II) and five patients had seizure reduced by 75% (Engel III). One patient had a < 75% seizure reduction (Engel IV). Two patients had temporary postoperative complications. One patient had deep sensory disturbance and one patient got aphasia. All recovered within three months. No permanent complications occur.
Conclusions:
As a minimally invasive, safe, and effective treatment for the drug-resistant insular epilepsy patients, SEEG-guided multiple electrode stereo-conformal RFTC can be a complementary treatment for resection surgery.
Funding:
National Natural Science Foundation of China (81790654)
Clinical Epilepsy