Structural Abnormalities in Juvenile Myoclonic Epilepsy
Abstract number :
3.263
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2022
Submission ID :
2204405
Source :
www.aesnet.org
Presentation date :
12/5/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:24 AM
Authors :
juhee Oh, MD – The catholic University of Korea St. Vincent's hospital; Seong-Hoon Kim, MD. PhD – Neurology – Catholic University of Korea, Uijeonbu St. Mary’s Hospital; Young-Min Shon, MD. PhD – Neurology – Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Sung Chul Lim, MD. PhD – Neurology – Catholic University of Korea, St. Vincent’s Hospital
Rationale: This study examined not only the gray and white matter changes of juvenile myoclonic epilepsy (JME) patients by using tract-based spatial statistics (TBSS), constrained laplacian-based anatomic segmentation with proximity (CLASP) algorithm, but also the subcortical volume loss from manual volumetry and 3D shape analysis using spherical harmonic based functions (SPHARM) algorithm. In addition, our study is intended to elucidate the changes of cortical thickness that is correlated to volume reduction of thalamus and hippocampus.
_x000D_
JME patients do not appear to have structural abnormalities following conventional neuroimaging. However, several studies that investigated JME patients have revealed microstructural and functional changes when using state-of-the-art imaging techniques._x000D_
Methods: We included 27 JME patients and 22 normal controls. For cortical thickness analysis, the CLASP algorithm was applied. 3D shape analysis of hippocampus and thalamus was performed automatically using the SPHARM algorithm.
Results: The results were the following:_x000D_
- Cortical structural changes: JME patients exhibited a significant reduction in cortical thickness in the dorsolateral frontal and anterolateral temporal cortex _x000D_
- Relevant subcortical structural changes: significant reduction in volume in the bilateral thalami and hippocampi _x000D_
- Changes of the surface thickness by SPHARM analysis: JME subjects showed a few clusters with more decreased surface thickness at middle and dorsal part of hippocampi and thalamic nucleus._x000D_
- Correlation of cortical structures with the hippocampal or thalamic volume loss: Significantly reduced cortical thickness correlated with the volume reduction of both hippocampi. It encompassed widespread cortical gray matters including superior and inferior temporal and orbitofrontal, and medial frontal region._x000D_
- Cortical regions correlated with the clinical variables: We found a cluster on the parietal region showing statistically negative correlation of where in surface thickness with the seizure frequency.
Conclusions: The use of combined imaging analyses in this study demonstrated widespread structural abnormalities in JME. Our results suggest that structural MRI changes of JME may be widespread rather than confined to well-known frontothalamic circuit.
Funding: None
Neuro Imaging