STUDIES ON CEREBROSPINAL FLUID IONIZED CALCIUM AND MAGNESIUM CONCENTRATIONS IN CONVULSIVE CHILDREN
Abstract number :
1.162
Submission category :
Year :
2003
Submission ID :
1919
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Hitoshi Yamamoto, Hiroshi Murakami, Noriko Kamiyama, Yusaku Miyamoto, Miho Fukuda Pediatrics, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan; Pediatrics, St. Marianna University, Kawasaki, Kanagawa, Japan; Pediatrics, St.Marianna Un
The levels of ionized calcium (iCa) and magnesium (iMg) were measured in the cerebrospinal fluid (CSF) of convulsive and non-convulsive children to investigate the relationship between seizure manifestation and CSF iCa and iMg levels. Standard levels of CSF iCa and iMg were also established.
CSF samples from twenty three patients, ages 0-15 years, with various forms of seizures and twenty six age-matched contrls were collected by lumbar puncture. CSF was obtained anaerobically and the concentrations of CSF iCa and iMg were measured with an electolyte analyzer ( Stat Profile Ultra, NOVA, U.S.A.) immediately.
The levels of CSF iCa were significantly higher in control children ages less than eleven months compared with children ages more than twelve months. The levels of CSF iMg in control children did not differ significantly with aging. The levels of CSF iCa in convulsive children did not differ significantly from control levels. The levels of CSF iMg in convulsive children were significantly lower than in controls.
These results suggest that seizure manifestation may be related to age-dependent changes in iCa and decreased iMg in the brain.