Abstracts

Rationale: Application of advanced treatment modalities, such as surgery, ketogenic diet, and newly-developed anti-epileptic drugs (AEDs). Could make successful seizure control of Lennox-Gastaut Syndrome (LGS) than conventional treatment.Methods: We reviewed 87 LGS patients, who could achieve seizure free for more than 2 years. We retrospectively observed their clinical profiles including etiology, electroencephalography(EEG) features, MRI findings, seizure characteristics, developmental progress, and outcome of various treatment modalities.Results: Of 386 LGS patients diagnosed at the pediatric epilepsy clinic, Severance Children’s Hospital, 87 cases could achieve seizure free for more than 2 years. Resective surgery showed significant numbers of seizure free outcome in 36 patients out of 105 patients (34.2%), and corpus callosotomy in 4 out of 56 patients (7.1%). KD could make seizure free outcome in 26 cases out of 134 cases (19.4%). New AEDs such as valproic acid, zonisamide, levetiracetam, lamotrigine and clobazam could make seizure free outcome mostly with polytherapy. There was significant benefits in developmental progress in patients who became seizure free.Conclusions: Active application of new treatment modalities including surgery, KD and new AEDs has promising outcome in significant proportion of patients suffering LGS.