Surgical Outcomes and Distinctions Between Genetic and Non-Genetic Epilepsy: A Single-Center Cohort Comparison Study Reveals Feasibility of Surgical Intervention
Abstract number :
2.362
Submission category :
12. Genetics / 12A. Human Studies
Year :
2023
Submission ID :
862
Source :
www.aesnet.org
Presentation date :
12/3/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Alina Ivaniuk, MD – Cleveland Clinic
Christian Boßelmann1, MD – Epilepsy Center – Cleveland Clinic; Xiaoming Zhang, PhD – Epilepsy Center – Cleveland Clinic; Lara Jehi, MD, MHCDS – Epilepsy Center – Cleveland Clinic; William Bingaman, MD – Epilepsy Center – Cleveland Clinic; Imad Najm, MD – Epilepsy Center – Cleveland Clinic; Elia Pestana-Knight, MD – Epilepsy Center – Cleveland Clinic; Dennis Lal, MD – Genomic Medicine Institute – Cleveland Clinic
Rationale: Many genetic epilepsy disorders are characterized by focal epilepsy or exhibit focal or lateralized features, which make individuals with such disorders potential surgical candidates. However, the role of genetic etiology in epilepsy surgery outcomes and value of genetic testing in presurgical assessment remains unclear.
Methods: This retrospective cross-sectional study included 610 people with epilepsy who underwent epilepsy surgery at Cleveland Clinic in years 1997 through 2022, of which 24 people had pathogenic germline variant-associated genetic epilepsy. We included individuals who underwent resective surgery or laser ablation, had either outcome or clinical information to estimate outcome documented, and had at least one year of follow-up. We compared extracted clinical variables between the groups using Kruskal-Wallis and Fisher exact tests as appropriate. We calculated longitudinal seizure recurrence rates with Kaplan-Meier survival analysis and used Cox proportional hazards model for multivariate analysis.
Results: Compared to non-genetic epilepsy patients, people with a genetic epilepsy were statistically significantly younger at seizure onset (1.5 years, IQR 0.2-7.0 vs. 12 years, IQR 4-12, p< 0.001
Genetics