Temporal manipulation of Cdkl5 reveals essential post-developmental functions and reversible CDKL5 deficiency disorder-related deficits
Abstract number :
3.397
Submission category :
1. Basic Mechanisms / 1E. Models
Year :
2021
Submission ID :
1886462
Source :
www.aesnet.org
Presentation date :
12/9/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:56 AM
Authors :
Zhaolan (Joe) Zhou, PhD - University of Pennsylvania;
Rationale: CDKL5 deficiency disorder (CDD) is an early-onset, neurodevelopmental syndrome associated with pathogenic variants in the X-linked gene encoding cyclin-dependent kinase-like 5 (CDKL5). CDKL5 has been implicated in neuronal synapse maturation, yet its post-developmental necessity and the reversibility of CDD-associated impairments remain unknown.
Methods: We temporally manipulated endogenous
Basic Mechanisms