THE ACUTE EFFECT OF MUSIC PERIODICITY ON ROLANDIC SPIKES: A RANDOMIZED, SINGLE-BLINDED, CROSSOVER, PILOT CLINICAL TRIAL OF THE ACUTE EFFECT OF MUSIC WITH LONG-TERM PERIODICITY AND REPEATED MELODIC LINE (M-LTP/RML) ON INTERICTAL SPIKE DISCHARGES (ISD) IN C
Abstract number :
1.159
Submission category :
Year :
2003
Submission ID :
3654
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Robert P. Turner Neurology, Pediatrics, and Neurological Surgery, Medical University of South Carolina, Charleston, SC
To investigate the effect of exposure to music with long-term periodicity and repeated melodic line (M-LTP/RML) on frequency of interictal spike discharges (ISDs) in children with Benign Childhood Epilepsy with Centrotemporal Spikes (BCECTS). The goal of this pilot study was to demonstrate decreased ISDs due to exposure to M-LTP/RML. Exposure to M-LTP/RML (Mozart[rsquo]s Sonata for Two Pianos, K. 448) has been shown to enhance spatial-temporal functioning. Both anti-epileptiform and anti-seizure properties of M-LTP/RLM have been demonstrated by the seminal work of John Hughes, without validation by clinical trial (Gates JR. Letter to the Editor: The Mozart effect. Epilepsy Behav 2002;3:483; Hughes JR. Review: The Mozart effect. Epilepsy Behav 2002;2:396-417). A mechanism of this effect, not due to relaxation or enjoyment of the music, has been proposed based on the trion model of Mountcastle[rsquo]s columnar organization of the neocortex (Rauscher FH, Shaw GL. Key components of the Mozart effect. Percept Mot Skills 1998;86:835-41; Shaw GL, Bodner M. Music enhances spatial-temporal reasoning: Towards a neurophysiological basis using EEG. Clin Electroencephalogr 1999;30:151-55).
Four subjects with BCECTS, 5-9 years, were recruited for this prospective, randomized, single-blinded, crossover, pilot clinical study. ISD frequency/minute was averaged over each of three periods/hour, over four hours of continuous EEG monitoring: (1) Silence: 15 min, (2) Exposure: M-LTP/RML or control (placebo) music (Beethoven[rsquo]s Für Elise) (18 min), and (3) Wash-out period: 27 min. Mean ISD count/epoch, standard deviations, variance, and correlation data were calculated.
A significant ([gt]30%) decrease in mean ISDs was demonstrated comparing baseline to exposure to M-LTP/RML, but not to control music, in two subjects demonstrating sufficient ISDs for data collection and statistical analysis.
Demonstration of decreased ISDs from exposure to M-LTP/RML indicates an effect on mechanisms of spike generation. If reproducible in a sufficiently powered prospective, randomized clinical trial, this effect would contribute to understanding epileptogenesis and new treatment strategies for aborting and preventing seizures. A larger clinical trial is proposed to study this effect on spikes as well as seizures, with subsequent studies of mechanisms indicated.
[Supported by: Outpatient General Clinical Research Center (GCRC), Medical University of South Carolina]