THE CHANGE OF HOMOCYSTEINE LEVEL BY POLYMORPHISM OF 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE AND METHIONINE SYNTHASE GENE IN EPILEPSY
Abstract number :
1.195
Submission category :
Year :
2003
Submission ID :
3940
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Ok Joon Kim Derpartment of Neurology, Pochon CHA University, Sungnam, Kyunggi-do, Republic of Korea
Hyperhomocysteinemia was observed in epileptic patients receiving anticonvulsants, especially homozygotes for mtehylenetetrahydrofolate reductase(MTHFR) gene C677T mutation. Recently, it has been reported that polymorphisms in methionine synthase (MS A2756G) also affects homocysteine level. Therefore, we examined if the type of MS as well as MTHFR gene affect the level of homocysteine in epileptic patients.
We investigated folate, Vit B12, homocysteine, MTHFR and MS gene in 181 patients with epilepsy. And then, we analyzed the change of folate, Vit B12, and homocysteine level according to the type of genes.
The level of folate and Vit B12 did not be affected by MTHFR and MS gene. But, the level of homocysteine was affected by each other or combination of MTHFR and MS gene. When MTHFR/MS gene type was CC/GG, CT/GG, TT/AA, and TT/AG, the level of homocysteine was elevated compared with other type.
We recommend higher vitamin supplement with antiepileptic drug in epileptic patients according to the gene type after examining MTHFR and MS gene.