Abstracts

Rationale:
It is important to predict prognosis of status epilepticus (SE). The aim of this study was to assess the prognostic significance of periodic discharges (PDs) on the functional outcome and the occurrence of refractory status epilepticus (RSE) of patients with SE.

Methods:
We analyzed the clinical history, neuroimaging data, routine EEG and continuous video-EEG monitoring records of consecutive patients with SE. We selected patients with PDs (PDs group) which composed more than 50% of the EEG recording. We excluded patients with anoxic brain damage, SE with simple focal seizure, absence SE or incomplete medical records. We compared PDs group with non-PDs group. Functional outcome at the time of hospital discharge was assessed by Modified Rankin Scale (MRS).

Results:
Among 86 consecutive patients with SE, fourteen patients were excluded. In 72 patients with SE, 31 patients were PDs group. Thirty eight out of 72 had good functional outcome (MRS 0-3) and 34 had bad functional outcome (MRS 4-6). The presence of PDs (p=0.033, odd ratio 3.65, 95% CI 1.11-12.04) and stuporous or comatose mental status at presentation (p=0.044, odd ratio 3.35, 95% CI 1.04-10.84) were independent risk factors for bad functional outcome in multivariate analysis. The occurrence of RSE was significantly higher in patients with PDs (p=0.001, odd ratio 11.05 95% CI 2.79-43.87).

Conclusions: PDs is an independent predictive factor of bad functional outcome and the occurrence of RSE. Therefore, patients with SE accompanied by PDs should be given early and rigorous management.

Funding: Nothing