THE INFLUENCE OF HIPPOCAMPAL SCLEROSIS EXTENT AND AMYGDALAR ATROPHY ON THE SECONDARY GENERALIZATION OF COMPLEX PARTIAL SEIZURES
Abstract number :
2.028
Submission category :
Year :
2003
Submission ID :
3758
Source :
www.aesnet.org
Presentation date :
12/6/2003 12:00:00 AM
Published date :
Dec 1, 2003, 06:00 AM
Authors :
Oh-Young Kwon, Imsuk Sung, Jae-Hyeong Kim, Ki-Jong Park, Nack-Cheon Choi, Byeong Hoon Lim Department of Neurology, Gyeongsang National University College of Medicine, Jinju, Gyeongnam, Korea; Department of Radiology, Seoul National University College of M
There were several presumptions that the hippocampal sclerosis extent and amygdalar atrophy contribute to secondary generalization of complex partial seizures of temporal lobe. We investigated the correlation between hippocampal sclerosis extent/amygdalar atrophy and the secondary generalization of complex partial seizures in temporal lobe epilepsy.
Thirty patients with both of the MRI evidence of hippocampal sclerosis and the clinical features of temporal lobe epilepsy were enrolled. The MRI studies, at the field strength of 1.5 Tesla, were performed with T1 and T2-weighted axial and T2-weighted coronal spin-echo images. Two neurologists and one neuroradiologist independently determined the extent of hippocampal sclerosis and amygdalar involvement using visual inspection. The patients were divided into paired groups according to the hippocampal sclerosis extent and amygdalar involvement. We analyzed the influence of hippocampal sclerosis extent and amygdalar atrophy on the secondary generalization of complex partial seizures.
Eight of 14 patients with partial hippocampal sclerosis (57.1%) and 2 of 16 patients with diffuse hippocampal sclerosis (12.5%) had the secondary generalization in more than 50% of complex partial seizures and the difference was statistically significant (p = 0.019). The amygdalar atrophy did not have statistically significant influence on secondary generalization.
The secondary generalization of complex partial seizures of temporal lobe epilepsy was more frequently occurred in the restricted form of hippocampal sclerosis than in the diffuse form. This implies that the preservation of some hippocampal structures may enhance the secondary generalization.