The North American Anti-Epileptic Drug Pregnancy Registry: A Canadian Subgroup Analysis
Abstract number :
3.41
Submission category :
4. Clinical Epilepsy / 4E. Women's Issues
Year :
2021
Submission ID :
1886518
Source :
www.aesnet.org
Presentation date :
12/6/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:56 AM
Authors :
Julien Hébert, MD, MSc, FRCPC - Columbia University/New York-Presbyterian Hospital; Esther Bui, MD, FRCPC – Division of Neurology – Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Susan Conant, Clinical Research Coordinator – The North American Antiepileptic Drug Pregnancy Registry, MassGeneral Hospital for Children, Boston, Massachusetts, USA; Lewis Holmes, MD – Medical Genetics and Metabolism Unit – MassGeneral Hospital for Children, Boston, Massachusetts, USA
Rationale: The North American AED Pregnancy Registry (NAAPR) provides crucial data for understanding the risks of AED exposure in pregnancy. This study aims to quantify the Canadian contribution to NAAPR, and assess AED usage in pregnancy among Canadian women.
Methods: Enrollment rate ratios (ERR) to NAAPR, adjusted for the relative size of populations of women of childbearing age, were calculated between Canada and the USA, and between the Canadian provinces and the Canadian average enrollment. Methods of enrollment to NAAPR and AED usage were compared between the two countries using chi-squared tests.
Results: Between 1997 and 2019, 10215 pregnant women enrolled into NAAPR: 4.1% were Canadian (n=432, ERR 0.39, CI95%= 0.35-0.43). Within Canada, no patients were enrolled from the three northern territories, or from Prince-Edward Island. While Quebec had a low relative enrollment rate (ERR 0.35, CI95%= 0.19-0.58), Nova Scotia had the highest rate of enrollment (ERR 1.55; CI95%= 0.66-3.11). Canadians were less likely to be enrolled to NAAPR via their healthcare provider than their American peers (p < 0.01). Canadian women were more likely to be taking carbamazepine (24%; p< 0.01) or valproic acid (21%; p< 0.01).
Clinical Epilepsy