Authors :
Presenting Author: Tatsuki SAITO, MS – Nagoya University
Koichi FUJIWARA, Associate Professor – Department of Materials Process Engineering, Nagoya University; Ryosuke SUZUI, MD – Department of Pediatrics, Nagoya University Graduate School of Medicine,; Jun NATSUME, Professor – Department of Developmental Disability Medicine, Nagoya University Graduate School of Medicine
Rationale:
West syndrome (WS) is an infantile epileptic encephalopathy defined on the basis of epileptic spasms and hypsarrhythmia on electroencephalogram (EEG), and is recognized to have a highly variable long-term prognosis from the viewpoint of spasm control, freedom from other seizure types and psychomotor development. Although the treatment of WS is crucial for patients and their families due to its poor developmental prognosis, its pathophysiology has not been fully understood. Fast oscillations (FOs) including gamma(40-80Hz) and ripples(80-200Hz) can be observed on infants' scalp EEG and has been investigated for prognosis prediction of WS. This study aimed to investigate whether the powers of specific frequency bands within FOs presence periods contribute to predicting the prognosis of WS or not.
Methods:
Eighteen infants with WS participated in this study, who were treated at the Nagoya University Hospital from 2007 to 2015. Their mean age at seizure onset was 5.2 months, and the follow-up period was 11.1 years on average. We measured their EEG by the international 10-20 system with a sampling rate of 500 Hz and used A1 and A2 averages as reference. The patients were classified into three outcome groups based on the presence of seizures and developmental quotients (DQs). The patients with DQs <