Abstracts

Rationale: The resting state fMRI study in Non lesional epilepsy patients, using the algorithm of low-frequency fluctuation observed amplitude increased and decreased in the circumstances, in order to understand the patients resting state brain activity and abnormal brain regions in non-focal seizures in the role. Methods: The low frequency fMRI were performed in non-lesional epilepsy group and normal controls group in non-attention state, 16 cases with a history of more than 2 years, aged 10-38 years,frequent grand mal epilepsy patients. After pre-processing of resting-state fMRI data,with which a whole-brain in low frequency fMRI fluctuations was calculated to investigate the changes of the Low-frequency amplitude changes. Results: Compared with normal subjects, the regions showing increased ALFF in NLE patients were distributed in right temporal lobe(15,-90,21),medial frontal lobe(0,24,-24),ventral anterior cingulate(-12,30,27)and the right cerebellar hemispher(51,-57,-4); (2) while the regions showing decreased ALFF covered the areas of the left cerebellar hemispher(-48,-15,39),posterior cingulum gyrus(60,-21,33)and precunens(-6,-54,66). Conclusions: (1) NLE patients shows abnormal brain functional organization in resting state.(2) The increased ALFF is considered the facilitation such as the epileptic activity generation and propagation;while the ALFF decreased is able to considered the function inhibition in these regions.