Abstracts

Rationale: There were few reports for the impact of electrolyte level to the occurrence of benign convulsion with mild gastroenteritis (CwG). We conducted this study to evaluate the effect of serum sodium and uric acid level on the pathogenic mechanism of CwG. Methods: We assessed 21 patients with CwG at Soonchunhyang University Cheonan Hospital, from January to December 2012. The patients' data included sex, age on visit, semiology, frequency and duration of seizure, seizure onset after gastroenteritis and serum sodium/uric acid level. As a control group, age matched patients presenting with only gastroenteritis during the same period　were　compared. Results: Nine boys and 12 girls were involved in the study as CwG group. Their mean age was 17.9±7.9 months. Eight patients (38.1%) visited hospital from November to December in terms of monthly distribution. The seizure types were generalized tonic clonic (71.4%), generalized tonic (23.8%) and atonic (4.8%). The duration of seizures was mostly within 5 minutes. The onset of seizures from gastroenteritis was mostly 1 to 3 days. Stool rotavirus antigen test were positive in 2 of 13 patients. Electroencephalography was performed in 14 patients, in which only three patients showed generalized delta activities without sharp wave/spike discharge. Brain MRI was performed in 13 patients and there was no abnormal finding. Their mean sodium level was 136.5±2.3 mmol/L and mean uric acid level was 8.8±2.0 mg/dL. Sixty eight boys and 35 girls were enrolled as a control group. Their mean age was 15.3±7.7 months. Mean sodium level was 139.2±2.6 mmol/L and mean uric acid level was 5.2±2.1 mg/dL. The differences in serum sodium and uric acid level between CwG and control group were statistically significant. Conclusions: This study showed the significant differences in both sodium and uric acid serum level between CwG and control group, which may contribute to the pathogenic mechanism of CwG. However, further prospective studies are needed