THE SIGNIFICANCE OF HOMOCYSTEINE IN EPILEPTIC PATIENTS
Abstract number :
3.132
Submission category :
Year :
2002
Submission ID :
1863
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Ok Joon Kim, Nam Keun Kim, Doyeun Oh, Byung Ok Choi, Sun Hee Kim. Neurology, Pundang CHA General Hopital, Yatap-dong, Pundang-gu, Sungnam, Kyonggi-do, Korea; Genetic institute, Pundang CHA General Hopital, Yatap-dong, Pundang-gu, Sungnam, Kyonggi-do, Kore
RATIONALE: Elevated homocyteine level(hyperhomocysteinemia) was observed in epileptic patients receiving anticonvulsants , especially with mtehylenetetrahydrofolate reductase (MTHFR) 677 TT genotype. Hyperhomocysteinemia induce atherosclerosis, fetal anticonvulsant syndrome, etc. So, we examined any other factors affecting the level of homocyteine in epileptic patients.
METHODS: We investigate the plasma total homocysteine level in 145 patients with epilepsy. And then, we analyzed various factors(clinical findings, neuro-image findings, drugs, MTHFR gene, serum folate and vitamine B12 level) affecting the level of homocysteine.
RESULTS: Among various factors, male, present neurological deficits, frequent seizure attacks, MTHFR 677 TT genotype, polypharmacy, and conventional drug(phenytoin, carbamazepine, valproic acid, phenobarbital, benzodiazpines) than new drug(lamotrigine, vigabatrin, topiramate, oxcarbazepine) were related with elevated homocysteine level.
CONCLUSIONS: We recommend monotherapy with new drugs and higher vitamin requirement in the male epileptic patients of MTHFR TT genotype with neurological deficits and frequent seizure attacks.
[Supported by: Ok Joon Kim]