Abstracts

Although seizures are important neurological manifestations or complications of CNS infection, there have been only a few studies. The purpose of this study was to determine the incidence, etiology, and clinical factors to predict acute symptomatic seizures with CNS infections., We retrospectively reviewed the medical records of patients with CNS infections from 2000 to 2005. We excluded patients with brain abscess, neurocysticercosis, and undetermined CNS infections, and 147 patients were finally included for this study. The clinical variables were analyzed between with and without acute symptomatic seizures., Of 147 patients , 23.2% (34/147) had acute symptomatic seizures. Univariate analysis revealed a significant relation between clinical variables and occurrence of acute symptomatic seizure; encephalitis as etiology of CNS infection [73.5%(25/34) vs 16.8%(19/113), [italic]p[lt]0.0001 by X[/italic][italic]² test[/italic]], Glasgow coma scale (GCS) [le] 12 at admission [73.5% (25/34) vs 28.3% (32/113), [italic]p[lt]0.0001 by X[/italic][italic]² test [/italic]], GCS [le] 14 at discharge [44.1% (15/34) vs 18.6% (21/113), [italic]p=0.005[/italic] by [italic]X[/italic][italic]² test[/italic] ] and abnormal neurologic examination at discharge [44.1%(15/34) vs 22.1% (25/113), p[italic]=0.02 by X[/italic][italic]² test [/italic]]. By multivariate analysis, age of onset [gt]42 years {OR 4.4, [95% CI (1.26-15.66)], [italic]p=0.02 [/italic]}, encephalitis {OR 13.9, [95% CI (4.60-42.25)], [italic]p[lt]0.0001 [/italic]}, and GCS [le]12 at admission {OR 10.3, [95% CI (3.12-34.28)], [italic]p=0.0001[/italic] } were still significant clinical variables to predict the occurrence of acute symptomatic seizures., Encephalitis and GCS [le]12 at admission are the significant clinical variables to predict the occurrence of acute symptomatic seizures in CNS infection, suggesting that the more parenchymal damaged, the more vulnerable to acute symptomatic seizures occur.,