Abstracts

RATIONALE:TISA, a new prospective method of seizure evaluation with quantitative data concerning changes of seizure and ictal semiology is now available with the use of video-EEG long-term monitoring. METHODS:8 patients with pharmacoresistant partial seizures undergoing presurgical evaluation were randomized in this double blind, placebo controlled, parallel add-on-therapy study of MHD under continuous video-EEG monitoring from the baseline phase to the end of MHD phase. Duration (lasting seconds of each seizure and semiology), intensity (0-4 grade), N/24h (numbers of attacks per 24 hours) and D/24h (seconds in 24 hours occupied by attacks of seizures and semiology) were recorded, also the Tint-B (interval of the last two seizures in baseline period) and Tint-B (interval from the beginning of MHD infusion to the occurence of the first seizure or to the study end in case no seizure recorded). Median values of ictal signs of each patient from different phases were compared between groups. And, changes of these ictal signs were further discussed using the Nucleus-Shell structure analytic model of seizures (Stefan 1998). RESULTS:Totally 68 seizures from the baseline and MHD phases were analyzed. 3 MHD patients(75%) had no seizures in the study phase. In MHD group, the summed decreasing percentage were: duration 57.75%, intensity 17%;Tint-B was 20.82h, Tint-A was 328h, the prolongation was significant. Duration and intensity of complex body movenments and hand move, and N/24h and D/24h of signs as oro-alimentary automatisms, fumbling, vocalization, hypomotor were improved clinically in MHD group. CONCLUSIONS:MHD is a relatively potent anticonvulsant, which acts on the nucleus of clinical seizure progression with an inhibitory effect. The method TISA is sensitive for evaluation changes of clinical signs under treatment.