Abstracts

Time to Treatment in Repeated Episodes of Pediatric Status Epilepticus

Abstract number : 1.217
Submission category : 4. Clinical Epilepsy / 4C. Clinical Treatments
Year : 2023
Submission ID : 123
Source : www.aesnet.org
Presentation date : 12/2/2023 12:00:00 AM
Published date :

Authors :
Presenting Author: Jennifer Gettings, BMBS, FRCPC, CSCN (EEG) – Boston Children's Hospital

Iván Sánchez Fernández, MD, MPH, MBI – Boston Children's Hospital; Anne Anderson, MD – Baylor College of Medicine; Nicholas Brenton, MD – University of Virginia; Justice Clark, MPH – Boston Children's Hospital; Raquel Farias Moeller, MD – Children's Hospital of Wisconsin; Marina Gaínza-Lein, MD, DipIBLM, PhD(c) – Boston Children's Hospital; Howard Goodkin, MD, PhD – University of Virginia; Yi-Chen Lai, MD – Baylor College of Medicine; Tobias Loddenkemper, MD – Boston Children's Hospital; Mohamad Mikati, MD – Duke University Medical Center; Lindsey Morgan, MD – Seattle Children's Hospital; Edward Novotny, MD – Seattle Children's Hospital; Adam Ostendorf, MD – Nationwide Children's Hospital; Juan Piantino, MD – Doernbecher Children’s Hospital; James Riviello, MD – Baylor College of Medicine; Kumar Sannagowdara, MD – Advocate Aurora Health Care; Robert Tasker, MBBS – Boston Children's Hospital; Dmitry Tchapyjnikov, MD – Logan Health Children’s Medical Center; Mark Wainwright, MD, PhD – Seattle Children's Hospital; Korwyn Williams, MD – Phoenix Children’s Hospital; Bo Zhang, PhD – Boston Children's Hospital

Rationale:
This study aims to compare the time to treatment in pediatric patients who present with a single episode of status epilepticus (SE) to those who have repeated episodes of SE.

Methods:
Retrospective analysis of a multicenter prospective observational cohort of pediatric patients with established SE and refractory SE with inpatient and out of hospital onset between 2011 and 2019.

Results:
Out of 504 SE episodes in 420 patients, 50 patients (10.3%) had repeated episodes of SE in their lifetime, totaling 134/504 (26.6%) of all SE episodes. In patients with repeated SE, a predictor of repeated SE was a prior diagnosis of epilepsy (p< 0.001). There was no difference in time to treatment with the first benzodiazepine (BZD) in patients presenting with their first SE episode compared to their second SE episode [median 10 (interquartile range (IQR) 5-30) minutes vs 14 (4.5 – 52.5) minutes; (p=0.24)] or in time to treatment with the first non-BZD anti-seizure medication (ASM) [61 (37-125) minutes vs 71 (34.5-117.5) minutes; p=0.61]. In patients with repeated SE episodes with onset outside the hospital, the percentage of patients treated by caregivers did not improve between the first and second SE episodes (61% vs 60%, p=0.56). However, the time to first BZD was shorter in patients treated by caregivers compared to those who were not [5 (0-25) minutes vs 55 (41-120) minutes; p< 0.001].
Clinical Epilepsy