Timing of Rescue Medication Administration and Seizure Cluster Termination
Abstract number :
3.283
Submission category :
7. Anti-seizure Medications / 7C. Cohort Studies
Year :
2023
Submission ID :
1193
Source :
www.aesnet.org
Presentation date :
12/4/2023 12:00:00 AM
Published date :
Authors :
Presenting Author: Sharon Chiang, MD, PhD – University of California
Robert Moss, N/A – Seizure Tracker; Sunita Misra, MD – Neurelis, Inc.; Enrique Carrazana, MD – University of Hawaii; Adrian Rabinowicz, MD – Neurelis, Inc
Rationale:
Seizure clusters are associated with morbidity and mortality and require prompt identification and treatment. However, the optimal timing of rescue medication administration relative to cluster onset is not well understood.
Methods:
Retrospective data were analyzed on benzodiazepine rescue medication administration and seizure timing from individuals with self-reported seizures (n=220) using the SeizureTracker database between December 1, 2007 and August 8, 2022. The mean number of focal impaired aware and bilateral tonic clonic seizures per seizure cluster was compared for various time frames of administration after cluster onset.
Results:
Rescue medication administration was associated with fewer seizures per cluster when given early in the seizure cluster across various empirical cluster definitions. An association with fewer seizures per cluster was present with rescue medication administered within 0-4 hours of clusters defined by an ISI<
Anti-seizure Medications