Transition of memory ability from preoperative to 2 years after operation in patients with refractory temporal lobe epilepsy
Abstract number :
3.348
Submission category :
11. Behavior/Neuropsychology/Language / 11A. Adult
Year :
2017
Submission ID :
349758
Source :
www.aesnet.org
Presentation date :
12/4/2017 12:57:36 PM
Published date :
Nov 20, 2017, 11:02 AM
Authors :
Hiroshi Hosoyama, Graduate School of Medical and Dental Sciences, Kagoshima University; Ryosuke Hanaya, Graduate School of Medical and Dental Sciences, Kagoshima University; Toshiaki Otsubo, Fujimoto general hospital; Noriko Tsumagari, Fujimoto general ho
Rationale: Patients in temporal lobe epilepsy are said to have memory impairment by causing hippocampal dysfunction. If it goes into refractory, it is regarded as a good indication for surgical treatment, but IQ and memory greatly changes from onset to preoperative and postoperative. We investigated the change in IQ and memory from preoperative to 2 years after operation in patients with refractory temporal lobe epilepsy who underwent epilepsy surgery retrospectively. Methods: Between 2007 to 2015, 20 patients who underwent focal resection for temporal lobe epilepsy performed at Kagoshima University Hospital or related institutions. All patients were; more than 2 years after operation passed, seizure outcome is Engel Class I, and WAIS or WISC and WMS-R were performed before preoperative, 3 months after operation, and 2 years after operation. Results: 20 patients were; 6 men and 14 women, mean age at onset was 21.9 years, mean disease duration was 10.5 years, and mean operative age was 32.4 years. postoperative seizure outcome was Engel Class Ia in 12, Ib in 4, Ic in 3, and Id in 1. In addition, side of surgery was 8 was in dominant hemisphere and 12 were non-dominant hemisphere. Preoperative memory ability was a tendency that ability to be lower for people who developed younger. In case of the shorter the duration of the disease and younger the operative age, the tendency was to increase the memory ability at 2 years after operation compared with the preoperative memory ability. In case of non-dominant hemispheric side resection, the memory ability at 2 years after operation was higher in all items than in the preoperative. In case of dominant hemispheric side resection, the memory ability at 2 years after surgery was higher by PIQ, attention concentration ability than in preoperative. In case of dominant side resection, There was no significant difference between the 4 cases of anterior temporal lobectomy and the 3 cases of selective amygdalohippocampectomy. Conclusions: Of patients with good seizure outcome, it was suggested that postoperative memory ability tends to rise as the duration of disease is shorter and the operative age is lower. It could be one of the reasons for recommending early operation of refractory temporal lobe epilepsy. Funding: none
Behavior/Neuropsychology