Authors :
Fiza wali, MBBS – Riphah International University (Islamic International Medical College)
Javeria Javeid, MBBS – University of Florida
Areej Javeid, MBBS – Allama Iqbal Medical College
Zain Ali Nadeem, MBBS – Allama Iqbal Medical College
Tabeer Zahid, MBBS – Foundation University Medical College (FUSH)
Rayyan Nabi, MBBS – drrayyannabi03@gmail.com
Samirna Hanif, MD – Marshall University
Presenting Author: Abdullah Zaki, MD – Marshall University School of Medicine
Syed Hashim Ali Inam, MD – Marshall University Joan C. Edwards School of Medicine, Department of Neurology
Rationale:
Cardiovascular disease (CVD) is one of the leading causes of morbidity and mortality worldwide, and patients with epilepsy have an elevated risk of CVD. Patients with epilepsy are particularly more prone to sudden cardiac death. However, contemporary data on the cardiovascular mortality in patients with epilepsy is lacking. We aim to determine the trends in cardiovascular mortality among patients with epilepsy in the United States (US) stratified by sex, race/ethnicity, census region, urbanization, and states.
Methods:
We obtained data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database for adults ( >25 years) in the U.S. from 1999 to 2020, with respiratory disease and epilepsy listed anywhere on the death certificates, either as the underlying or a contributing cause of death. Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) were calculated per 100,000 people, along with 95% confidence intervals (CIs). We used the Joinpoint Regression Program to analyze temporal trends by calculating the annual percent change (APC) in the rates. A P-value < 0.05 was considered statistically significant.