Use of the NeuroPace RNS System at a Typical Level 4 Academic Center
Abstract number :
1.08
Submission category :
2. Translational Research / 2A. Human Studies
Year :
2021
Submission ID :
1826138
Source :
www.aesnet.org
Presentation date :
12/9/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:52 AM
Authors :
Elliot Neal, MD - Unversity of South Florida; Angelica Rivera-Cruz – University of South Florida; Yarema Bezchlibnyk – University of South Florida; Lionel Dacpano – NeuroPace; Selim Benbadis – University of South Florida; Stephanie Maciver – University of South Florida; Ushtar Amin – University of South FLorida
Rationale: The responsive neurostimulation (RNS) System was approved in the US in 2013 and is now a standard treatment option for refractory focal epilepsy that is available at many level 4 epilepsy centers. Here we describe the clinical application of the NeuroPace RNS System at a typical level 4 academic center.
Methods: A retrospective review of 24 patients who were treated at the University of South Florida with the RNS System was included in this study. Clinical seizure frequencies at baseline and last follow-up visit were collected for patients that had the RNS System placed for at least six months. Seizure frequency outcomes were determined by using a patient questionnaire during clinic. RNS System lead type and location, follow-up duration, resection locations, and outcomes after resections data were collected for all patients.
Results: Twenty-four patients received the RNS System and were followed for an average of 3.18 years. Twenty-two patients had adequate seizure frequency reports in their charts. Seventy-three percent (16/22) of our patients had a 50% or more reduction in seizure frequency as compared to baseline. Thirty-two percent (7/22) had a >90% or more reduction. Two patients were seizure free. Eighteen patients had seizure severity data available. Eighty-three percent (15/18) of those patients reported having “less severe seizures” and 39% (7/18) reported having “much less severe seizures” as compared to their pre-RNS System baseline. Two patients underwent resections post RNS System placement, which were guided by the long-term data from the RNS System. One of those patients became seizure free. Seven patients had an active RNS and VNS being used in combination. There were no adverse events related to surgery or stimulation side effects reported in any patient.
Conclusions: In this group of patients treated with the RNS System, the frequency of seizures was reduced, with a responder rate of 73%, as was the severity, and the treatment was well tolerated. One patient had a resection where the RNS System data played a direct role in informing the surgery that provided 100% seizure freedom.
Funding: Please list any funding that was received in support of this abstract.: N/A.
Translational Research