Abstracts

Rationale: The toxicity associated with antiepileptic drugs (AEDs) is one of the parameters to consider assessing the response to treatment (ILAE Classification 2010). Perucca described that 61% of patients treated with AEDs have at least one adverse event (AE). However, the evaluation of toxicity depends on the AE patients and report of physicians. The underreporting from physicians may limit the usefulness of the new classification. Methods: Forthe report of physicianst we use an AE report form (CIOMS). In a database was recorded, AEDs exposure, casualty analysis and outcome. AE were classified according to the mechanism of production classification proposed by Perucca. For patients reporting we use a validated Spanish version survey (Liverpool Adverse Event Profile). Results: Year 2007 was taken to estimate the real incidence of AE reported by physicians (1.44%). 320 surveys were conducted, where patients reported 4800 AE, leading to a AE patients report incidence of 15%. AE were classified according to the mechanism of production in type A (dose dependent), B (idiosyncratic) and C (chronic). Conclusions: There is a clear unbalance between the report of AE by physicians and spontaneous reporting of patients conducted with a specific instrument. The use of a specific method facilitates the classification of response to treatment with AEDs.