Abstracts

Rationale: Rationale: Corpus callosotomy is well known to provide some measure of control of atonic seizures. Seizures associated with apnea are equally as difficult to control with AEDs. We present here three cases of children with medically intractable epilepsy and seizures associated with apnea in which corpus callosotomy was performed for seizure reduction.Methods: Methods: A retrospective chart review was done of the frequency of seizures associated with apnea in three patients who went underwent corpus callosotomyResults: Results: all three patients underwent corpus callosotomies, with mean follow up of 34 months (range 11 to 72 months, age at surgery ranged from 36 to 186 months (mean 91 months) Two had genetic abnormalities. The two boys had a 100% reduction in seizures associated with apnea, while the girl (older at time of surgery) experienced a reduction of about two thirds. The two boys who underwent surgery at a younger age experienced abetter outcomes. All also experienced complete cessation of their atonic seizures. One boy who had experienced episodes with desats down to 50% has not experienced any desats. Conclusions: Conclusions: Corpus callosotomy proved to be an effective treatment for seizures associated with apnea (as well as atonic seizures) in this group of patients with medically intractable epilepsy.