Abstracts

Rationale: The effects of electromagnetic waves (EMWs) on humans and their relationship with various disorders have been investigated. We aimed to investigate the effects of exposure to different frequencies of EMWs in various durations in a mouse epilepsy model induced by pentylenetetrazole (PTZ). Methods: Total 180, four-week-old male mice weighing 25-30 g were used in this study. Each experimental group consisted of 10 mice. They were exposed to 900, 700, 500, 300 and 100 MHz EMWs in 20 hours, 12 hours and 2 hours. Following electromagnetic radiation exposure, 60 mg/kg of PTZ was injected intraperitoneally to all mice. Each control was also injected PTZ without any exposure to EMW. The latency of initial seizure and most severe seizure onset were compared with controls. Results: The shortest initial seizure latency was noted in the 500 MHz and the longest in the 300 MHz in 2 hours group. The shortest initial seizure latency was noted in the 700 MHz and the longest in the control group, followed by the 100 MHz in 12 hours group. The shortest initial seizure latency was noted in the 300 MHz and the longest in the 500 MHz in 20 hours group. No statistically significant difference was noted in terms of the latency of the most severe seizure following 20, 12 and 2 hours of EMW exposure. Conclusions: Our results suggested that exposure to different frequencies and different duration of EMWs had different effects on epileptic seizure latency. Further studies are needed.